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  • Pharmachologic effect
  • Method of administration and dosage
  • Contraindications
  • Overdose
  • Interaction with other drugs

    Paroxetine is a potent and selective 5-hydroxytryptamine (5-HT, serotonin) reuptake inhibitor. It is believed that its antidepressant activity and efficacy in the treatment of obsessive-compulsive (OCD) and panic disorder are due to the specific inhibition of serotonin reuptake in the neurons of the brain.

    By its chemical structure, paroxetine differs from tricyclic, tetracyclic and other known antidepressants. Paroxetine has a weak affinity for muscarinic cholinergic receptors, and animal studies have shown that it has only weak anticholinergic properties. In accordance with the selective action of paroxetine, in vitro studies have shown that, unlike tricyclic antidepressants, it has a weak affinity for α1-, α2- and β-adrenergic receptors, as well as for dopamine (D2), 5-HT1-like, 5HT2 - and histamine (H1) receptors.

    This lack of interaction with postsynaptic receptors in vitro is confirmed by the results of in vivo studies, which demonstrated the lack of ability of paroxetine to depress the central nervous system and induce arterial hypotension. Pharmacodynamic effects Paroxetine does not impair psychomotor functions and does not increase the depressing effect of ethanol on the central nervous system. Like other selective serotonin reuptake inhibitors, paroxetine produces symptoms of 5-HT receptor overstimulation when administered to animals that have previously received MAO inhibitors or tryptophan. Behavioral and EEG studies have demonstrated that paroxetine produces mild activating effects at doses in excess of those required to inhibit serotonin reuptake.

    Its activating properties are not "amphetamine-like" in nature. Animal studies have shown that paroxetine does not affect the cardiovascular system. In healthy individuals, paroxetine does not cause clinically significant changes in blood pressure, heart rate and ECG. Studies have shown that, unlike antidepressants, which inhibit the reuptake of norepinephrine, paroxetine has a much lower ability to inhibit the antihypertensive effects of guanethidine.

    Method of administration and dosage

    Paroxetine is recommended to be taken 1 time / day in the morning with meals. The tablet should be swallowed whole without chewing. Depression The recommended dose in adults is 20 mg / day.

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    My feedback on the antidepressant Paxil

    Paxil belongs to the group of SSRIs - that is, selective serotonin reuptake inhibitors. They are safe and modern drugs, with a minimum of side effects when compared to older generation antidepressants. The principle of Paxil's action is that it prevents the breakdown of the hormones of happiness and joy, thereby heals depressive states and other problems of a person's mental state. I know that Paxil is also used for panic attacks, but I drank it precisely because of a depressive, depressed state. I wrote that it HEALS depression - it really is - after a course of admission without violations, you just become a different person. And after the drug is canceled, you remain. True, when a traumatic situation occurs in life again, misfortune, then depression returns.

    And generic Paxil helped me a little over a month, prescribed 100 pieces. The first month was terrible, I slept almost all the time, although I felt better. In the second month, sleep returned to normal, I will not say that the joy in life returned, but it became much better. And in the third month, there was some kind of rollback. I needed an operation, AST and alt indicators were off scale, so I finished everything at once without a slow refusal from the drug, unpleasant consequences did not keep me waiting. Where to buy generic Paxil? It was as if an electric discharge ran through my head every minute, but this, however, would not have happened if only gradually. Now 2 months have passed since the drug, the state has almost returned to its original state, the memory has become a total nix, my 26 can hardly remember the names, the right numbers, addresses, etc. Apparently everything is individual and it did not suit me.

    I cannot say that only these pills helped me. They gave me the push I needed. The psychotherapist told me during the first session that nothing would help me until I completely changed myself, my worldview, character, etc. And yes, I am constantly working on myself. Smile I have read a lot of psychological literature, I have changed, now I take everything positively, I am not upset about trifles. Nothing pisses me off, because I have a golden rule NOTHING IS WORTH MY NERVES. I SHOULD TAKE CARE OF MYSELF AND GET ONLY POSITIVE EMOTIONS.

    Needless to say, with a change in outlook on life, I also changed outwardly. Smile I don't wear jeans and shapeless sweaters at all, I fell in love with skirts, dresses, blouses, coats and heels. I found harmony within myself. It seems to me that this is the most important thing in life.

    Yes, I am a little worried about canceling the drug, because there may also be side effects, but this is no longer scary to me. I am even to some extent grateful to the panic attacks for the fact that they banged me so and gave an incentive to change. Maybe I would continue to be dissatisfied with the life of the clams)

    Prescribed generic Paxil 20 mg per day. I have been drinking it for 5 years now, I can't quit, a very strong withdrawal syndrome! Against the background of Paxil, the condition is excellent, but after cancellation, it becomes bad on the 2-3rd day. Nausea, severe dizziness, tremors, chills, fever, insomnia. The state is terrible! The chill is such that I can't sit still! The head is spinning so that it's scary to leave the house, everything floats in my eyes. For a week I tried to overcome all this, but it didn't get any worse or better, and I started drinking Paxil again. I tried many times to quit Paxil and various methods were prescribed to me, and gradually reducing the dose and abruptly, nothing helps. The last year I have not even tried to leave him!

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